Precision Science Group
(PSG)
TNFR1 Antibody
TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD.
Alternative Name(s)
CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRSF1A; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor
Application
WB
UNIprot
P19438
clonality
Monoclonal
reactivity
Human, Mouse, Rat
Research area
Cell Biology
source
Mouse
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
TNFR1 Antibody