Precision Science Group
(PSG)
SYVN1 Antibody
Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).
Alternative Name(s)
1200010C09Rik; DER3; E3 ubiquitin-protein ligase synoviolin; HMG coA reductase degradation 1 homolog; HRD1; KIAA1810; MGC40372; OTTHUMP00000230429; OTTHUMP00000230430; OTTHUMP00000230431; OTTHUMP00000230432; Synovial apoptosis inhibitor 1; Synovial apoptosis inhibitor 1, synoviolin; Synoviolin 1 isoform b; SYNOVIOLIN; SYVN1; SYVN1_HUMAN;
Application
WB
UNIprot
q86tm6
clonality
Monoclonal
reactivity
Human, Mouse, Rat
Research area
Cell Biology->Proteolysis / Ubiquitin->Proteasome / Ubiquitin->Ubiquitin E3 Enzymes->Ring Finger E3 Ligase;Cell Biology->Apoptosis->Intracellular->Survivin / Iaps;Epigenetics And Nuclear Signaling->Ubiquitin & Ubiquitin Like Modifiers->E3 Ubiquitin Ligases
source
Mouse
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
SYVN1 Antibody