top of page

SYVN1 Antibody

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).

Alternative Name(s)

1200010C09Rik; DER3; E3 ubiquitin-protein ligase synoviolin; HMG coA reductase degradation 1 homolog; HRD1; KIAA1810; MGC40372; OTTHUMP00000230429; OTTHUMP00000230430; OTTHUMP00000230431; OTTHUMP00000230432; Synovial apoptosis inhibitor 1; Synovial apoptosis inhibitor 1, synoviolin; Synoviolin 1 isoform b; SYNOVIOLIN; SYVN1; SYVN1_HUMAN;

Application

WB

Read More >

UNIprot

q86tm6

clonality

Monoclonal

reactivity

Human, Mouse, Rat

Research area

Cell Biology->Proteolysis / Ubiquitin->Proteasome / Ubiquitin->Ubiquitin E3 Enzymes->Ring Finger E3 Ligase;Cell Biology->Apoptosis->Intracellular->Survivin / Iaps;Epigenetics And Nuclear Signaling->Ubiquitin & Ubiquitin Like Modifiers->E3 Ubiquitin Ligases

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

SYVN1 Antibody

bottom of page