Precision Science Group
(PSG)
SFPQ (578) mAb
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC,CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion.
Alternative Name(s)
SFPQ100 kDa DNA-pairing protein; 100 kDa subunit; DNA-binding p52/p100 complex; DNA-binding p52/p100 complex, 100 kDa subunit; hPOMp100; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing facto; polypyrimidine tract-binding protein-associated splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor; POMP100; protein phosphatase 1, regulatory subunit 140; PSF; PTB-associated splicing factor; PTB-associated-splicing factor; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated); splicing factor proline/glutamine-rich; Splicing factor, proline- and glutamine-rich; 1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik; AU021830; D4Ertd314e; Gm12940; OTTMUSG00000009329; POMP100; PPP1R140; PSF; REP1; SFPQ
Application
WB, IF
UNIprot
P23246
clonality
Monoclonal
reactivity
Human,Mouse,Rat
Research area
Epigenetics And Nuclear Signaling
source
Mouse
storage
Store at -20℃, stable for one year from the date of shipment.
SFPQ (578) mAb