Precision Science Group
(PSG)
PRP19 Antibody
Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234).
Alternative Name(s)
NMP200; nuclear matrix protein 200; pre-mRNA-processing factor 19; PRP19; PRP19/PSO4; PRPF19; PSO4; senescence evasion factor; SNEV; UBOX4;
Application
WB,IHC,ICC,FCM
UNIprot
q9ums4
clonality
Monoclonal
reactivity
Human,Mouse,Rat
Research area
Epigenetics And Nuclear Signaling
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
PRP19 Antibody