Precision Science Group
(PSG)
phospho-TFE3(Ser565) Antibody
Transcription factor that specifically recognizes and binds E-box sequences (5quot;-CANNTG-3quot;) (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1.
Alternative Name(s)
bHLH e33; bHLHe33; Class E basic helix-loop-helix protein 33; RCCP 2; RCCP2; RCCX1; Renal cell carcinoma, papillary; Tcfe 3; Tcfe3; TFE 3; Tfe3; TFE3_HUMAN; TFEA; Transcription factor binding to IGHM enhancer 3; Transcription factor E family, member A; Transcription factor E3; Transcription factor for IgH enhancer; Transcription factor for immunoglobulin heavy chain enhancer 3;
Application
WB IF/IHC
UNIprot
P19532
clonality
Polyclonal Antibody
reactivity
Human, Mouse, Rat
Research area
Immunology
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
phospho-TFE3(Ser565) Antibody