Precision Science Group
(PSG)
Phospho-STUB1/CHIP (Ser19) Antibody
E3ubiquitin-proteinligasewhichtargetsmisfoldedchaperonesubstratestowardsproteasomaldegradation.CollaborateswithATXN3inthedegradationofmisfoldedchaperonesubstrates:ATXN3restrictingthelengthofubiquitinchainattachedtoSTUB1/CHIPsubstratesandpreventingfurtherchainextension.UbiquitinatesNOS1inconcertwithHsp70andHsp40.Modulatestheactivityofseveralchaperonecomplexes,includingHsp70,Hsc70andHsp90.Mediatestransferofnon-canonicalshortubiquitinchainstoHSPA8thathavenoeffectonHSPA8degradation.MediatespolyubiquitinationofDNApolymerasebeta(POLB)atquot;Lys-41quot;,quot;Lys-61quot;andquot;Lys-81quot;,therebyplayingaroleinbase-excisionrepair:catalyzespolyubiquitinationbyamplifyingtheHUWE1/ARF-BP1-dependentmonoubiquitinationandleadingtoPOLB-degradationbytheproteasome.MediatespolyubiquitinationofCYP3A4.UbiquitinatesEPHA2andmayregulatethereceptorstabilityandactivitythroughproteasomaldegradation.Actsasaco-chaperoneforHSPA1AandHSPA1Bchaperoneproteinsandpromotesubiquitin-mediatedproteindegradation.NegativelyregulatesthesuppressivefunctionofregulatoryT-cells(Treg)duringinflammationbymediatingtheubiquitinationanddegradationofFOXP3inaHSPA1A/B-dependentmanner.LikelymediatespolyubiquitinationanddownregulatesplasmamembraneexpressionofPD-L1/CD274,animmuneinhibitoryligandcriticalforimmunetolerancetoselfandantitumorimmunity.NegativelyregulatesTGF-betasignalingbymodulatingthebasallevelofSMAD3viaubiquitin-mediateddegradation.MayregulatemyosinassemblyinstriatedmusclestogetherwithUBE4BandVCP/p97bytargetingmyosinchaperoneUNC45Bforproteasomaldegradation.MediatesubiquitinationofRIPK3leadingtoitssubsequentproteasome-dependentdegradation.
Alternative Name(s)
Antigen NY CO 7; Antigen NY-CO-7; C terminus of Hsp70-interacting protein; Carboxy terminus of Hsp70 interacting protein; Carboxy terminus of Hsp70-interacting protein; Carboxy terminus of Hsp70p interacting protein; CHIP; CHIP_HUMAN; CLL associated antigen KW 8; CLL-associated antigen KW-8; E3 ubiquitin protein ligase CHIP; E3 ubiquitin-protein ligase CHIP; Heat shock protein A binding protein 2 (c terminal); HSPABP2; NY CO 7; PP1131; SDCCAG7; Serologically defined colon cancer antigen 7; STIP1 homologyand U Box containing protein 1; STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase; STIP1 homology and U box-containing protein 1; STUB 1; STUB1; UBOX 1; UBOX1;
Application
WB IF/IHC
UNIprot
Q9UNE7;Q9UNE7;
clonality
Polyclonal Antib
reactivity
Human; Mouse; Rat
Research area
Epigenetics And Nuclear Signaling
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
Phospho-STUB1/CHIP (Ser19) Antibody