Phospho-PI3-kinase p85- alpha/ gamma (Tyr467/199) pAb

Phosphatidyl i nos ital 3-kinase regu la to叩subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene. Phosphatidylinositol 3-kinase phosphorylates the inositol 「ing of phosphatidylinositol at the 3-p『ime position. The enzyme comprises a 110 kD catalytic subunit and a 『egu latory subunit of eithe「 85, 55, o「 50 kD. This gene encodes the 85 kD 『egu latory subunit. Phosphatidylinositol 3-kinase plays an i『npo『tant role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin 「esistance. Alte「native splicing of this gene results in three transcript variants encoding diffe「·ent isoforms.