Precision Science Group
(PSG)
Phospho-MBD7(pS86) antibody
Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed:25684209).Requires high mCG density for binding (PubMed:25684209, PubMed:25593350).Recognizes preferentially mCGs located in transposable elements (PubMed:25684209, PubMed:25593350).Required for active DNA demethylation (PubMed:25593350).Prefers to target genomic loci around chromocenters (PubMed:25593350).
Alternative Name(s)
Phospho-MBD7(pS86),Methyl-CpG-binding domain-containing protein 7; MBD07; Methyl-CpG-binding protein MBD7;
Application
WB,IHC/IF
UNIprot
Q9FJF4; At5g59800
clonality
Polyclonal
reactivity
Arabidopsis thaliana
Research area
Others
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
Phospho-MBD7(pS86) antibody