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Phospho-IRE1 (S724) Antibody

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Alternative Name(s)

ERN1, ER to nucleus signalling 1, Inositol-requiring enzyme 1, Inositol-requiring protein 1, Ire1-alpha, IRE1a, HIRE1p, IRE1, Inositol-requiring 1, IRE1P;

Application

WB

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UNIprot

o75460

clonality

Monoclonal

reactivity

Human

Research area

Signal Transduction

source

Rabbit

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

Phospho-IRE1 (S724) Antibody

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