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Phospho-IKB alpha(pS32+pS36) Antibody

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Alternative Name(s)

I kappa B alpha; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; IKBA_HUMAN; IKBalpha; MAD 3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappa-B inhibitor alpha; NFKBI; NFKBIA; Nuclear factor of kappa light chain gene enhancer in B cells; Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor alpha;

Application

WB

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UNIprot

p25963

clonality

Monoclonal

reactivity

Human, Mouse, Rat

Research area

Signal Transduction

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

Phospho-IKB alpha(pS32+pS36) Antibody

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