Precision Science Group
(PSG)
Phospho-Akt(Ser473) Antibody
an AGC kinase that plays a critical role in controlling the balance between survival and AP0ptosis. Phosphorylated and activated by PDK1 in the PI3 kinase pathway. Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. First found in a mouse transforming retrovirus. Tumorigenic in a mouse lymphoma model and activated (by phospho-Akt staining) and/or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Inhibitor: RX-0201. Substrates include tuberin, Bad, Forkhead transcription factors, caspase-9, and glycogen synthase kinase-3.
Alternative Name(s)
AKT, AKT1 kinase, C-AKT, EC 2.7.11.1, PKB, PKB-alpha, Protein kinase B, RAC, RAC-PK-alpha, RAC-alpha serine/threonine kinase, kinase Akt1
Application
WB,IHC,IF/ICC
UNIprot
P31749
clonality
Polyclonal
reactivity
Human,Mouse,Rat
Research area
Others
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
Phospho-Akt(Ser473) Antibody