Precision Science Group
(PSG)
PHD1/prolyl hydroxylase Antibody
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Alternative Name(s)
Estrogen-induced tag 6; HPH-3;
Application
WB,IHC,ICC/IF,FCM
UNIprot
q96ks0
clonality
Monoclonal
reactivity
Human,Mouse,Rat
Research area
Cancer->Cancer Metabolism->Response To Hypoxia;Cancer->Invasion/Microenvironment->Apoptosis->Caspases;Cancer->Invasion/Microenvironment->Apoptosis->Detection Kits->Annexin V;Cancer->Invasion/Microenvironment->Angiogenesis->Angiogenic Growth Factors;Cancer->Invasion/Microenvironment->Angiogenesis->Ecm Enzymes->Kallikreins;Cancer->Invasion/Microenvironment->Hypoxia->Hif;Metabolism->Pathways And Processes->Metabolism Processes->Hypoxia;Cardiovascular->Hypoxia->Prolyl Hydroxylase;Epigenetics And Nuclear Signaling->Cardiovascular/Immune->Hypoxia->Prolyl Hydroxylase
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
PHD1/prolyl hydroxylase Antibody