Precision Science Group
(PSG)
PDHA1 mAb
The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO, and provides the primary link between glycolysis and the tricarboxylic acid cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase , dihydrolipoamide acetyltransferase and lipoamide dehydrogenase. The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Name(s)
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialmitochondrial; PDHA1; pdha1a; pdha1b; PHE1A; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase E1 alpha 1; Pyruvate dehydrogenase E1 component subunit alpha; somatic form
Application
WB
UNIprot
P08559
clonality
Monoclonal
reactivity
Human,Mouse,Rat
Research area
Signal Transduction; Metabolism
source
Mouse
storage
Store at -20℃, stable for one year from the date of shipment.
PDHA1 mAb