Miro antibody

Mitochondrial GTPase involved in mitochondrial trafficking (PubMed:16055062, PubMed:16717129, PubMed:22396657).Forms an essential protein complex with Milt that links Khc to mitochondria for light chain-independent, anterograde transport of mitochondria (PubMed:16717129).Required for axonal transport to synapses within nerve terminals (PubMed:16055062, PubMed:22396657).Required presynaptically but not postsynaptically at neuromuscular junctions (NMJs) (PubMed:16055062).Also involved in the regulation of mitochondrial dynamics by promoting drp1-mediated mitochondrial fission during high calcium conditions, and negatively regulating fission during normal conditions (PubMed:27716788).