MBD7 antibody

Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. May directly affect chromatin structure by inducing intra- and inter- chromatin compaction via bridging over multiple methylated CpG sites. Acts as an anti-silencing factor that prevents DNA hypermethylation and gene repression (PubMed:25684209).Requires high mCG density for binding (PubMed:25684209, PubMed:25593350).Recognizes preferentially mCGs located in transposable elements (PubMed:25684209, PubMed:25593350).Required for active DNA demethylation (PubMed:25593350).Prefers to target genomic loci around chromocenters (PubMed:25593350).