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KMT5A Antibody

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.

Alternative Name(s)

Si:dkey-23a23.2; N-lysine methyltransferase KMT5A-B-like isoform X1;

Application

WB

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UNIprot

A0A2R8QE11

clonality

Monoclonal

reactivity

Danio_rerio

Research area

Others

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

KMT5A Antibody

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