Precision Science Group
(PSG)
JMJD2A Antibody
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
Alternative Name(s)
JHDM3A; JmjC domain containing histone demethylation protein 3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain containing histone demethylase 3A; Jumonji domain containing 2; Jumonji domain containing 2A; Jumonji domain containing protein 2A; Jumonji domain-containing protein 2A; KDM4A; KDM4A_HUMAN; KIAA0677; Lysine (K) specific demethylase 4A; Lysine-specific demethylase 4A; TDRD14A; Tudor domain containing 14A;
Application
WB, IP, IF
UNIprot
O75164
clonality
Monoclonal
reactivity
Human,Mouse,Rat
Research area
Epigenetics And Nuclear Signaling
source
Mouse
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
JMJD2A Antibody