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IkB-α(N-term) Mouse mAb

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription

Alternative Name(s)

I-kappa-B-alpha; NFKBI; NFKBIA; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappaB inhibitor alpha; IKBA; IkappaBalpha; MAD3; RL/IF-1

Application

WB

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UNIprot

P25963

clonality

Monoclonal

reactivity

Human,Mouse

Research area

Signal Transduction

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

IkB-α(N-term) Mouse mAb

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