Precision Science Group
(PSG)
HIF Prolyl Hydroxylases Antibody
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Alternative Name(s)
EGLN4 ; HIFPH4; Hypoxia inducible factor prolyl 4 hydroxylase; P4H with transmembrane domain; P4htm; PH4; PHD4; Proline 4 hydroxylase; Prolyl hydroxlase domain containing 4;
Application
WB IHC IP FC
UNIprot
Q9NXG6
clonality
Monoclonal
reactivity
Human
Research area
Cancer->Invasion/Microenvironment->Apoptosis->Death Receptors & Ligands->Traf;Cancer->Invasion/Microenvironment->Angiogenesis->Angiogenic Growth Factors;Cancer->Invasion/Microenvironment->Angiogenesis->Other;Cardiovascular->Hypoxia->Prolyl Hydroxylase;Epigenetics And Nuclear Signaling->Cardiovascular/Immune->Hypoxia->Prolyl Hydroxylase
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
HIF Prolyl Hydroxylases Antibody