HCV NS5A protein Antibody

Phosphorylated protein that is indispensable for viral replication and assembly (PubMed:31511391). Both hypo- and hyperphosphorylated states are required for the viral life cycle (PubMed:31511391). The hyperphosphorylated form of NS5A is an inhibitor of viral replication (By similarity). Involved in RNA-binding and especially in binding to the viral genome (PubMed:20592076). Zinc is essential for RNA-binding (By similarity). Participates in the viral particle production as a result of its interaction with the viral mature core protein (PubMed:18524832). Its interaction with host VAPB may target the viral replication complex to vesicles (By similarity). Down-regulates viral IRES translation initiation (By similarity). Mediates interferon resistance, presumably by interacting with and inhibiting host EIF2AK2/PKR (By similarity). Prevents BIN1-induced apoptosis (By similarity). Acts as a transcriptional activator of some host genes important for viral replication when localized in the nucleus (By similarity) (PubMed:30281972). Via the interaction with host PACSIN2, modulates lipid droplet formation in order to promote virion assembly (By similarity). Modulates TNFRSF21/DR6 signaling pathway for viral propagation (By similarity).