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HAUSP/USP7 Mouse mAb

Hydrolase that deubiquitinates target proteins such as FOXO4,p53/TP53,MDM2,ERCC6,DNMT1,UHRF1,PTEN and DAXX.Together with DAXX,prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53,thereby promoting p53/TP53 ubiquitination and proteasomal degradation.Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2,and also induces p53/TP53-dependent cell growth repression and apoptosis.

Alternative Name(s)

TEF1; HAUSP; USP7;

Application

WB

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UNIprot

Q93009

clonality

Monoclonal

reactivity

Human

Research area

Epigenetics And Nuclear Signaling; Microbiology; Cell Biology; Cancer

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

HAUSP/USP7 Mouse mAb

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