FTO Mouse mAb (2F8)

FTO, also known as Fatso or KIAA1752, is a 505 amino acid protein that has anN-terminal nuclear localization signal. Expressed in a variety of tissues, withhighest levels present in brain and pancreatic tissue, Fatso exists as fouralternatively spliced isoforms, once of which is associated with apredisposition to childhood and adult obesity. Due to its involvement in thedevelopment of obesity, Fatso is associated with an increased BMI and may beinvolved in the pathogenesis of type 2 diabetes. The gene encoding Fatsomaps to human chromosome 16, which encodes over 900 genes and comprisesnearly 3% of the human genome. The GAN gene is located on chromosome 16and, with mutation, may lead to giant axonal neuropathy, a nervous systemdisorder characterized by increasing malfunction with growth. The raredisorder Rubinstein-Taybi syndrome is also associated with chromosome 16,as is Crohn's disease, which is a gastrointestinal inflammatory condition.