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Envelopment polyprotein G1

Forms homotetramers with glycoprotein C at the surface of the virion. Attaches the virion to host cell receptors including integrin beta3/ITGB3 (PubMed:16310165). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (PubMed:11886265). Also promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion. May dysregulate normal immune and endothelial cell responses through an ITAM motif.

Alternative Name(s)

GP; Glycoprotein precursor; M polyprotein; Glycoprotein G1;

Application

WB

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UNIprot

P08668

clonality

Monoclonal

reactivity

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)

Research area

Virus

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

Envelopment polyprotein G1

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