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Cleaved Notch1 (Val1744) Antibody

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting.

Alternative Name(s)

NOTC1, NOTCH1, TAN1, hN1, neurogenic locus notch homolog protein 1, neurogenic locus notch homolog protein 1 precursor;

Application

WB IHC/IF

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UNIprot

p46531

clonality

Monoclonal

reactivity

Human, Mouse, Rat

Research area

Neuroscience

source

Mouse

storage

Store at -20 ℃. Stable for 12 months from date of receipt.

Cleaved Notch1 (Val1744) Antibody

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