Calcitonin[2H4] mAb

The most prominent clinical syndrome associated with a disordered hypersecretion of Calcitonin (CT) is medullary carcinoma of the thyroid (MTC). MTC is a tumor of the Calcitonin producing C-cells of the thyroid gland. Although MTC is rare, comprising 5 - 10% of all thyroid cancer, it is often fatal. Further, it leant itself to be diagnosed early by serum Calcitonin and total cure for early sub-clinical disease is possible. Neoplastic disorders of other neuroendocrine cells can also elevate Calcitonin. The best example is small cell lung cancer. Other tumors such as carcinoids and islet cell tumors of the pancreas can also result in elevated serum Calcitonin. Increases in serum Calcitonin has also been noted in both acute and chronic renal failure, hypercalciuria and hypercalcemia.