Precision Science Group
(PSG)
Anti-PYCARD Antibody
Functionsaskeymediatorinapoptosisandinflammation.Promotescaspase-mediatedapoptosisinvolvingpredominantlycaspase-8andalsocaspase-9inaprobablecelltype-specificmanner.Involvedinactivationofthemitochondrialapoptoticpathway,promotescaspase-8-dependentproteolyticmaturationofBIDindependentlyofFADDincertaincelltypesandalsomediatesmitochondrialtranslocationofBAXandactivatesBAX-dependentapoptosiscoupledtoactivationofcaspase-9,-2and-3.Involvedinmacrophagepyroptosis,acaspase-1-dependentinflammatoryformofcelldeathandisthemajorconstituentoftheASCpyroptosomewhichformsuponpotassiumdepletionandrapidlyrecruitsandactivatescaspase-1.Ininnateimmuneresponsebelievedtoactasanintegraladapterintheassemblyoftheinflammasomewhichactivatescaspase-1leadingtoprocessingandsecretionofproinflammatorycytokines.ThefunctionasactivatingadapterindifferenttypesofinflammasomesismediatedbythepyrinandCARDdomainsandtheirhomotypicinteractions.Requiredforrecruitmentofcaspase-1toinflammasomescontainingcertainpatternrecognitionreceptors,suchasNLRP2,NLRP3,AIM2andprobablyIFI16.IntheNLRP1andNLRC4inflammasomesseemsnotberequiredbutfacilitatestheprocessingofprocaspase-1.IncooperationwithNOD2involvedinaninflammasomeactivatedbybacterialmuramyldipeptideleadingtocaspase-1activation.MaybeinvolvedinDDX58-triggeredproinflammatoryresponsesandinflammasomeactivation.Isoform2mayhavearegulatingeffectonthefunctionasinflammasomeadapter.Isoform3seemstoinhibitinflammasome-mediatedmaturationofinterleukin-1beta.IncollaborationwithAIM2whichdetectscytosolicdouble-strandedDNAmayalsobeinvolvedinacaspase-1-independentcelldeaththatinvolvescaspase-8.InadaptiveimmunitymaybeinvolvedinmaturationofdendriticcellstostimulateT-cellimmunityandincytoskeletalrearrangementscoupledtochemotaxisandantigenuptakemaybeinvolvedinpost-transcriptionalregulationoftheguaninenucleotideexchangefactorDOCK2;thelatterfunctionisproposedtoinvolvethenuclearform.Alsoinvolvedintranscriptionalactivationofcytokinesandchemokinesindependentoftheinflammasome;thisfunctionmayinvolveAP-1,NF-kappa-B,MAPKandcaspase-8signalingpathways.ForregulationofNF-kappa-Bactivatingandinhibitingfunctionshavebeenreported.ModulatesNF-kappa-BinductionattheleveloftheIKKcomplexbyinhibitingkinaseactivityofCHUKandIKBK.ProposedtocompetewithRIPK2forassociationwithCASP1therebydown-regulatingCASP1-mediatedRIPK2-dependentNF-kappa-Bactivationandactivatinginterleukin-1betaprocessing.
Alternative Name(s)
Apoptosis associated speck like protein containing a CARD; Apoptosis-associated speck-like protein containing a CARD; ASC; ASC_HUMAN; CARD 5; CARD5; Caspase recruitment domain containing protein 5; Caspase recruitment domain protein 5; Caspase recruitment domain-containing protein 5; hASC; MGC10332; PYCARD; PYD and CARD domain containing; PYD and CARD domain containing protein; PYD and CARD domain-containing protein; Target of methylation induced silencing 1; Target of methylation-induced silencing 1; TMS 1; TMS; TMS1;
Application
WB IF/IHC
UNIprot
Q9ULZ3
clonality
polyclonal
reactivity
Human, Mouse, Rat
Research area
Cell Biology
source
Rabbit
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
Anti-PYCARD Antibody