Precision Science Group
(PSG)
Anti-Proinsulin C-A claevage junction Antibody
Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.This antibody direct against an epitope in the region of PLALEGSLQKRGIV sequence of human Proinsulin (which spans the C-A claevage junction).
Alternative Name(s)
Insulin; Insulin A chain; Insulin B chain; Insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; preproinsulin; proinsulin; IDDM; IDDM1; IDDM2; ILPR; INS; Ins-1; Ins-2; Ins1; Ins2; IRDN; MODY10;
Application
WB
UNIprot
P01308
clonality
Monoclonal
reactivity
Human
Research area
Signal Transduction; Cardiovascular; Metabolism; Neuroscience; Cancer
source
Mouse
storage
Store at -20 ℃. Stable for 12 months from date of receipt.
Anti-Proinsulin C-A claevage junction Antibody