Precision Science Group
(PSG)
alpha Actinin 4 (ACTN4) mAb
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
Alternative Name(s)
Alpha-actinin-4ACTN4, FSGS, FSGS1, ACTININ-4
Application
WB
UNIprot
O43707
clonality
Monoclonal
reactivity
Human,Mouse,Rat
Research area
Protein Transport
source
Mouse
storage
Store at -20℃, stable for one year from the date of shipment.
alpha Actinin 4 (ACTN4) mAb