AHASS1 antibody

Regulatory subunit of acetohydroxy-acid synthase. Involved in the feed-back inhibition by branched-chain amino acids. Contains 2 repeats, each of them being able to activate partially the catalytic subunit. The enzyme reconstituted with the first repeat is inhibited by leucine, but not by valine or isoleucine and the enzyme reconstituted with the second repeat is not inhibited by any branched-chain amino acid. In vitro, inhibited by valine and leucine, but not isoleucine. Involved in valine and leucine homeostasis. Required for reproductive development and sodium homeostasis.