SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity.
SUN2 mAb
SKU: M25116
SUN2nuclear envelope protein; Protein unc-84 homolog B; Rab5-interacting protein; Rab5IP; Sad1 unc-84 domain protein 2; Sad1/unc-84 protein-like 2; SUN domain-containing protein 2; unc-84 homolog B;FRIGG; KIAA0668; RAB5IP; SUN2; UNC84B